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KMID : 1191520080130010013
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Journal of Korean Traditional Oncology
2008 Volume.13 No. 1 p.13 ~ p.24
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Effects of Bikihuan (BKH) on anti-angiogenesis
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Kim Dae-Jun
Park Bong-Ky
Lee Yeon-Weol
Yoo Hwa-Seung
Han Sung-Soo
Cho Chong-Kwan
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Abstract
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Objective: To evaluate the effects of Bikihaun (BKH) on angiogenesis.
Method: We examined the anti-angiogenic effect of BKH in invasion assay model. We performed proliferation assay, migration assay, tube formation assay and Chicken Chorioallantoic Membrane (CAM) assay.
Results: In proliferation assay, at lower dose under 125 anti-angiogenesis effect of the group treated BKH made no difference with the control group. But, at the dose of 250 or more anti-angiogenesis effect of the group treated BKH showed more effective as compared to the control group. In migration assay, BKH did not affect migration of vascular endothelial cell. In tube formation assay, at lower dose under 100 showed mild effect of anti-tube formation. But, at the dose of 1000 showed more effective anti-tube formation. In CAM assay, BKH showed anti-angiogenesis effect at the dose of 10 .
Conclusion: BKH has antiangiogenetic properties in vitro.
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KEYWORD
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Bikihaun, angiogenesis, human umbilical vein endothelial cells, basic fibroblast growth factor
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